Survival Factors for Mesothelioma Highlighted by University of Pittsburgh Medical Center

According to GLOBOCAN 2018 statistics, each year there are 30,443 mesothelioma cases worldwide, and of those 30,443, 25,576 pass away.  With close to 85 percent of those diagnosed succumbing to the disease, mesothelioma remains one of the most deadly cancers as there is no cure. However, surviving a mesothelioma diagnosis is not entirely impossible as certain genetic and clinical factors play a part in determining how an individual reacts to the disease and its treatment.

Scientists and researchers from the University of Pittsburgh Medical Center (UPMC) recently published in the Lancet Respiratory Medicine six factors associated with higher percentages of survival in patients suffering from mesothelioma. These factors have remained largely unchanged throughout the nearly 30 years this study was conducted, but continue to be relevant when finding the best course of treatment for this disease. These six factors that contribute to better survival are as follows:

  • Female
  • Peritoneal mesothelioma
  • Under 45 years of age
  • Epithelioid subtype
  • Stage 1 of disease
  • Surgery  and chemotherapy

Data was collected from the National Mesothelioma Virtual Bank. This bank was developed in 2006 and is responsible for gathering human mesothelioma specimens for research.  By collecting paraffin embedded tissues, fresh frozen tissue, tissue microarrays, blood samples, and geonomic DNA,  research is then conducted research using these specimens to study biomarkers, immunology, genetics, and therapeutics. The National Mesothelioma Virtual Bank is at four facilities: New You University School of Medicine, Mount Sinai School of Medicine, University of Pennsylvania and, University of Pittsburgh Medical Center.

Between 1990 and 2017, 888 patients were studied to investigate those six factors associated with survival.

Age and Gender

Age of diagnosis has always been a factor for those suffering from mesothelioma. Generally, the younger a person is diagnosed, the better the chances are for survival.  The average survival time is around 12 months after initial diagnosis, but for those under the age of 45, rate of survival is about 59 months, or close to five years. Those diagnosed at 75 or older may live on average of only 10 months.

Unfortunately, the vast majority of those suffering from mesothelioma are older, as the average age of diagnosis is 69 years.  This is because the latency period between first exposure to asbestos and the time of diagnosis can span decades. Those exposed to asbestos in their 20s may not have symptoms of mesothelioma or any other asbestos-caused disease until after retirement – well into their  70s and beyond. On average, females have a 22-month survival.

Type of Mesothelioma

The mesothelium surrounding the lungs and lining the chest cavity is called the pleura, so mesothelioma affecting the cells lining the sacs surrounding the chest or lungs is referred to as pleural mesothelioma.

When the cancer affects the abdominal lining, or peritoneum, it is called peritoneal mesothelioma.

Malignant peritoneal mesothelioma is an extremely rare cancer. Only 100 to 500 cases are diagnosed in the US each year, making up less than 30 percent of all mesothelioma cases. Like pleural mesothelioma, peritoneal mesothelioma is often diagnosed when the malignancy is in the advanced stages. However, the average survival time for those with peritoneal mesothelioma is more than double than those with pleural mesothelioma – upwards of 30 months.

The cell type  – epithelioid, biphasic, and sarcomatoid – also may indicate survival rates. Patients with sarcomatoid cell type are faced with a seven-month survival median, while those with biphasic cell-type have an average of 10 months. Patients with epithelioid sub type have the greatest advantage, as their median survival is 18 months.

Stage of Disease, Chemotherapy and Surgery

Those diagnosed with stage 1 mesothelioma have a higher rate of survival than those diagnosed in the later stages of the disease. This is true for almost all cancers, but with mesothelioma, it is seldom the cancer is found in the early stages, which contributes to the high fatality rates associated with the asbestos-caused cancer. Typically, mesothelioma is not detected until symptoms begin. The median survival period is 20 months for those diagnosed with stage 1 disease and 12 months for those with stages 3 and 4.

Despite promising results from clinical trials and immunotherapy treatments, there is only one FDA approved chemotherapy treatment, pemetrexed. Surgery is also used in the treatment of malignant mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it and depending how far the cancer has spread, a lung also may be removed. Those who are able to receive both chemotherapy and surgery have a median survival of 23 months. However, surgery is not an option for those with mesothelioma. Patients need to be in good overall health and strong enough to withstand such an invasive procedure and the difficult recovery that follows. Fatality rates associated with surgery for pleural mesothelioma are often higher.

The factors that contribute to an overall better survival for those suffering from mesothelioma has largely remained unchanged over the years. Getting diagnosed when younger, in earlier stages, and while in good overall health has a tremendous impact on how the treatment of the disease moves forward. However, research efforts continue to grow and scientists and researchers are hopeful that with combination therapies, new treatments such as immunotherapy, and upcoming clinical trials will offer new insight on how to combat this fatal disease. Most recently, a $ 10.7 million grant was awarded to the University of Pennsylvania for their continued research and understanding of CAR-T cell therapy.

Sources:

“Pleural Mesothelioma: Tacking a Deadly Cancer,” The Lancet Respiratory Medicine (January 16, 2019). [Link]

Wagas Amin, et.al. “National Mesothelioma Virtual Bank: A Platform for Collaborative Research and Mesothelioma Biobanking Resource to Support Translational Research,” Lung Cancer International (September 2013). [Link]

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Last update: April 01, 2019. 03:30:08 pm.