Purpose: mesothelioma is an incurable cancer involving the lining of the lung. Patients usually suffer progressive symptoms of shortness of breath and chest pain, until they ultimately succumb to the disease. While a very small number of patients qualify for aggressive treatment with surgery, chemotherapy and radiation, and enjoy long-term survival, the vast majority of patients have incurable disease. The treatment options currently available, including chemotherapy and radiation treatment, are only modestly effective at alleviating symptoms and improving life expectancy. This trial explores the use of new radiation technology (tomotherapy), to treat mesothelioma more aggressively than has been possible before. Tomotherapy’s ability to treat unusual shaped tumours, particularly when they are wrapped around sensitive normal tissues (the lung), enable higher doses of radiation to be used and this may improve its effectiveness. We will treat 17 patients with tomotherapy and assess the breathing, symptoms, and quality of life of the patients before and after treatment
- Added: June 23rd, 2014.
- Last updated: June 23rd, 2014.
Primary Outcome Measure:
- Quality of Life [ Time Frame: 6 months ] [Designated as safety issue: Yes] Disease-specific symptom control rate post-treatment, based on Palliation Index .
Secondary Outcome Measures:
- Breathing Function [ Time Frame: 6 months ] [ Designated as safety issue: Yes ] Pulmonary function test results at 1, 3 and 6 months post treatment
- Survival/Response Rate [ Time Frame: 6 months ] [ Designated as safety issue: Yes ] performance status at 1, 3 and 6 months post treatment; and overall survival
- Inclusion Criteria:
- Exclusion Criteria:
- Contraindications to thoracic radiotherapy
- Unable to lie flat for duration of radiation therapy
Source: the U.S. National Institutes of Health via ClinicalTrials.gov. Last updated: June 23rd, 2014.
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